EXPERIMENTAL STUDY ON CONFINED COMPRESSION DEFORMATION AND BREAKAGE CHARACTERISTICS FOR DIFFERENT TYPES OF COAL PARTICLES

Experimental study on confined compression deformation and breakage characteristics for different types of coal particles

Dynamic disasters such as coal and gas outburst seriously restrict the safety of mine production.Different types of coal particles reflect the coal structure, mechanical characteristics and energy storage behavior under load, which is of great significance to the study of coal and gas outburst disasters.However, Eyebrow Pencil there is little resea

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Determination of the starting dose in the first-in-human clinical trials with monoclonal antibodies: a systematic review of papers published between 1990 and 2013

Hoon Young Suh,1 Carl C Peck,2 Kyung-Sang Yu,1 Howard Lee1,3 1Department of Clinical Pharmacology and Therapeutics, College of Medicine, Seoul National University Hospital, Seoul, Korea; 2Department of Bioengineering and Therapeutic Sciences, School of Pharmacy, University of California, San Francisco, CA, USA; 3Department of Transdisciplinary Stud

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FM1-43 is a permeant blocker of mechanosensitive ion channels in sensory neurons and inhibits behavioural responses to mechanical stimuli

Abstract The molecular identity and pharmacological properties of mechanically gated ion channels in sensory neurons are poorly understood.We show that FM1-43, a styryl dye used to fluorescently label cell membranes, permeates mechanosensitive ion channels in cultured Nutritionals - Pediatric dorsal root ganglion neurons, resulting in blockade of t

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